This Chicken Bubble Biscuit Bake Casserole is the ultimate comfort food — creamy, cheesy, and satisfying. With tender pieces of chicken, fluffy biscuit pieces, and a rich, savory sauce, it’s a one-pan meal that’s perfect for busy weeknights or cozy family dinners. The combination of creamy soup, sour cream, and melted cheese creates a luscious texture that everyone will love.

Why You’ll Love This Recipe

You’ll love this recipe because it’s quick to assemble, uses simple ingredients, and delivers all the flavors of a classic chicken bake with minimal effort. It’s hearty, family-friendly, and endlessly adaptable. The biscuits bake up golden and fluffy, soaking in the creamy sauce and making every bite irresistible.

Ingredients

(Tip: You’ll find the full list of ingredients and measurements in the recipe card below.)

• 2 cups cooked chicken, shredded or diced
• 1 can (10.5 ounces) cream of chicken soup
• 1 cup sour cream
• 1 teaspoon garlic powder
• 1 teaspoon onion powder
• 1 cup shredded cheddar cheese (plus extra for topping, optional)
• 1 can refrigerated biscuit dough (about 8 biscuits), cut into quarters
• Salt and black pepper to taste
• 1 tablespoon chopped fresh parsley (optional, for garnish)

Directions

1. Preheat the oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish.
2. In a large mixing bowl, combine the cream of chicken soup, sour cream, garlic powder, onion powder, salt, and pepper. Stir until smooth.
3. Add the shredded chicken and cheddar cheese, mixing until everything is evenly coated.
4. Cut each biscuit into quarters and gently fold them into the chicken mixture, ensuring that each piece is coated in the sauce.
5. Spread the mixture evenly into the prepared baking dish.
6. Sprinkle additional cheese on top if desired.
7. Bake uncovered for 25–30 minutes, or until the biscuits are cooked through and the top is golden brown and bubbly.
8. Let the casserole rest for 5 minutes before serving. Garnish with fresh parsley if desired.

Servings and timing

Servings: 6
Prep time: 10 minutes
Cook time: 30 minutes
Total time: 40 minutes

Variations

• Vegetable Mix: Add 1 cup of frozen mixed vegetables or broccoli florets for extra color and nutrition.
• Spicy Twist: Stir in ¼ teaspoon of chili powder or paprika for a gentle kick.
• Cheese Lovers: Mix in a blend of mozzarella and cheddar for a creamier texture.
• Ranch Style: Replace garlic and onion powder with a packet of ranch seasoning for a zesty twist.

Storage/Reheating

Store leftovers in an airtight container in the refrigerator for up to 3 days. To reheat, place a portion in the microwave for 1–2 minutes, or reheat in the oven at 325°F (160°C) until warmed through. Avoid overcooking to prevent the biscuits from drying out.

FAQs

Can I use rotisserie chicken for this recipe?

Yes, rotisserie chicken works perfectly and saves time. Just remove the skin and shred the meat.

Can I make this casserole ahead of time?

Yes, you can assemble it up to a day in advance and refrigerate it. Bake it just before serving.

What can I use instead of canned soup?

You can substitute with 1 cup of homemade white sauce (made with butter, flour, milk, and chicken broth).

Can I freeze this casserole?

It’s best to freeze it before baking. Cover tightly and freeze for up to 2 months. Bake from frozen, adding 10–15 minutes to the cook time.

Can I use low-fat sour cream?

Yes, but full-fat sour cream gives a creamier texture and richer flavor.

Do I need to pre-cook the biscuits?

No, the biscuits will bake perfectly in the sauce as the casserole cooks.

Can I add vegetables to this recipe?

Absolutely. Broccoli, peas, carrots, or corn make great additions.

How do I know when it’s done baking?

The casserole is ready when the biscuits are golden brown and cooked through in the center.

What cheese works best?

Sharp cheddar gives a strong, classic flavor, but Monterey Jack or Colby also work well.

Can I make this dish dairy-free?

Use dairy-free sour cream, cheese, and a non-dairy condensed soup substitute to make it dairy-free.

Conclusion

This Chicken Bubble Biscuit Bake Casserole is comfort food at its finest — creamy, cheesy, and incredibly satisfying. It’s a quick weeknight meal that pleases both kids and adults alike. Whether you make it for a cozy dinner or a casual gathering, this dish will become a go-to favorite in your home.

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