This one-pot Cajun chicken penne is the perfect blend of creamy, cheesy, and mildly spicy flavors. With tender chicken, hearty pasta, fresh spinach, and a rich three-cheese sauce, this dish comes together quickly in a single pot, making it ideal for busy weeknights.

Why You’ll Love This Recipe

• Made entirely in one pot for easy cleanup
• Creamy and comforting with three delicious cheeses
• Perfect balance of Cajun spice without overwhelming heat
• Protein-rich and filling
• Family-friendly and quick enough for weeknight dinners

Ingredients

(Tip: You’ll find the full list of ingredients and measurements in the recipe card below.)

2 tablespoons olive oil
1 pound boneless, skinless chicken breasts, cut into bite-sized pieces
1 tablespoon Cajun seasoning
1 teaspoon garlic powder
1/2 teaspoon salt
1/4 teaspoon black pepper
12 ounces penne pasta
4 cups chicken broth
2 cups fresh spinach
1 cup heavy cream
1/2 cup grated Parmesan cheese
1/2 cup shredded mozzarella cheese
1/2 cup crumbled feta cheese
1/4 cup chopped fresh parsley (for garnish)

Directions

1. Heat the olive oil in a large pot or Dutch oven over medium heat. Add the chicken pieces, Cajun seasoning, garlic powder, salt, and black pepper. Cook for 5–7 minutes, stirring occasionally, until the chicken is browned and cooked through.
2. Add the penne pasta and chicken broth to the pot. Bring to a boil, then reduce the heat and let it simmer. Cover and cook for 10–12 minutes, stirring occasionally, until the pasta is al dente and most of the liquid is absorbed.
3. Stir in the fresh spinach and heavy cream. Cook for 2–3 minutes, just until the spinach wilts.
4. Remove from heat and stir in the Parmesan, mozzarella, and feta cheeses until melted and creamy.
5. Serve warm, garnished with chopped parsley.

Servings and timing

Serves: 4
Prep time: 10 minutes
Cook time: 20 minutes
Total time: 30 minutes

Variations

• For extra heat, add diced jalapeños or a splash of hot sauce while cooking the chicken.
• Swap chicken for shrimp for a lighter, seafood version.
• Use turkey sausage or halal beef sausage for a flavorful twist.
• Add mushrooms or bell peppers for extra vegetables.
• Replace penne with rotini or farfalle if preferred.

Storage/Reheating

Store leftovers in an airtight container in the refrigerator for up to 3 days.
Reheat gently on the stovetop over low heat or in the microwave, adding a splash of broth or cream to restore creaminess.
This dish does not freeze well due to the creamy sauce.

FAQs

How spicy is Cajun chicken penne?

It has a mild to moderate heat, but you can adjust the Cajun seasoning to control the spice level.

Can I use pre-cooked chicken?

Yes, add it after the pasta cooks and heat it through before adding creams and cheeses.

Can I substitute the heavy cream?

You can use half-and-half, but the sauce may be slightly thinner.

What other cheeses can I use?

Try cheddar, gouda, or Monterey jack if you want to experiment with different flavors.

Does the pasta need to be cooked beforehand?

No, it cooks right in the broth with the chicken.

Can I add more vegetables?

Absolutely—spinach, tomatoes, zucchini, or bell peppers all work well.

How can I make the dish less spicy?

Use half the Cajun seasoning or choose a mild version.

What if the sauce is too thick?

Add a splash of chicken broth or cream to loosen it.

What if the sauce is too thin?

Let it simmer uncovered for a few minutes until it thickens.

Can I make this recipe dairy-free?

Use dairy-free cheeses and a plant-based cream alternative, though the texture will differ.

Conclusion

This one-pot Cajun chicken penne offers a comforting, flavorful meal with minimal cleanup and maximum satisfaction. Packed with tender chicken, creamy sauce, and perfectly cooked pasta, it’s a dish you’ll want to make again and again.

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